TARGETING INFLAMMATION TO TREAT DEPRESSION?

The relationship between chronic low-grade inflammation and depression represents a paradigm shift in our understanding of the pathophysiology of depression. It suggests that depression is not solely a disorder of neurotransmitter imbalance but rather a multifactorial condition involving dysregulation of immune-inflammatory pathways. Targeting inflammation may therefore represent a promising avenue for the development of novel therapeutic interventions for depression, particularly for individuals who do not respond adequately to conventional treatments.